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Version: 17.06d (Release date: 2017-06-26)
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Epacadostat (Code C92582)

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Terms & Properties

Preferred Name: Epacadostat

Definition: An orally available hydroxyamidine and inhibitor of indoleamine 2,3-dioxygenase (IDO1), with potential immunomodulating and antineoplastic activities. Epacadostat targets and binds to IDO1, an enzyme responsible for the oxidation of tryptophan into kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, INCB024360 increases and restores the proliferation and activation of various immune cells, including dendritic cells (DCs), NK cells, and T-lymphocytes, as well as interferon (IFN) production, and a reduction in tumor-associated regulatory T cells (Tregs). Activation of the immune system, which is suppressed in many cancers, may inhibit the growth of IDO1-expressing tumor cells. IDO1 is overexpressed by a variety of tumor cell types and DCs.

Display Name: Epacadostat

Label: Epacadostat

NCI Thesaurus Code: C92582 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL423831  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2,5-Oxadiazole-3-carboximidamide, 4-((2-((Aminosulfonyl)amino)ethyl)amino)-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-, (C(Z))-
INCB 024360

External Source Codes: 
CAS Registry Number 1204669-58-8 (see NLM ChemIDplus info)
FDA UNII Code 71596A9R13
PDQ Closed Trial Search ID 685310
PDQ Open Trial Search ID 685310 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C92582
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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