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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Docetaxel (Code C92581)

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Terms & Properties

Preferred Name: Liposomal Docetaxel

Definition: A formulation of the poorly soluble, semi-synthetic, second-generation taxane docetaxel encapsulated within liposomes, with antineoplastic activity. Upon intravenous administration, docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This liposomal formulation solubilizes docetaxel without the use of toxic solvents such as Tween 80, permitting the administration of larger doses of docetaxel while avoiding solvent-associated toxicity, including hypersensitivity reactions. In addition, liposomal delivery of docetaxel improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects while lowering the toxicity profile.

Display Name: Liposomal Docetaxel

Label: Liposomal Docetaxel

NCI Thesaurus Code: C92581 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL423830  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LE-DT
Liposomal Docetaxel
Liposome Entrapped Docetaxel

External Source Codes: 
PDQ Closed Trial Search ID 684963
PDQ Open Trial Search ID 684963 (check for NCI PDQ open clinical trial info)
NCI META CUI CL423830

Other Properties:
     Name Value (qualifiers indented underneath)
code C92581
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92581

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