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Version: 17.06d (Release date: 2017-06-26)
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Roniciclib (Code C92579)

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Terms & Properties

Preferred Name: Roniciclib

Definition: An orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. Roniciclib selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are often dysregulated in cancerous cells.

Display Name: Roniciclib

Label: Roniciclib

NCI Thesaurus Code: C92579 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL423828  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAY1000394
Roniciclib
RONICICLIB

External Source Codes: 
CAS Registry Number 1223498-69-8 (see NLM ChemIDplus info)
FDA UNII Code 0W9Q8U337A
PDQ Closed Trial Search ID 684718
PDQ Open Trial Search ID 684718 (check for NCI PDQ open clinical trial info)
NCI META CUI CL423828

Other Properties:
     Name Value (qualifiers indented underneath)
code C92579
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92579

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