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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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[18F]L-FAC (Code C92576)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: [18F]L-FAC

Definition: A deoxycytidine analog and high-affinity substrate for deoxycytidine kinase (DCK), labeled with fluorine F 18, with potential diagnostic activity upon positron emission tomography (PET) imaging. [18F]L-FAC is preferentially taken up by and accumulated in cells with high deoxycytidine kinase (DCK) levels, such as in tumor cells with dysregulated nucleoside metabolism. Upon uptake through the nucleoside transporter, [18F]L-FAC is phosphorylated by DCK and, subsequently, the 18F moiety can be visualized upon PET imaging. As many nucleoside analog prodrugs are chemotherapeutic agents that require DCK for activation, [18F]L-FAC can potentially be used as a marker to predict chemotherapeutic efficacy of these prodrugs. In addition, as DCK is upregulated in certain immune cells, such as activated T-cells, [18F]L-FAC can also be used to measure immune activation in response to immunomodulating agents. DCK, a rate-limiting enzyme in the nucleoside salvage pathway for DNA synthesis, is overexpressed in certain solid tumors, lymphoid and myeloid malignancies and certain immune cells, such as proliferating T-lymphocytes.

Display Name: [18F]L-FAC

Label: [18F]L-FAC

NCI Thesaurus Code: C92576 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2985185  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-(2-Deoxy-2-[18F]fluoroarabinofuranosyl) Cytosine

External Source Codes: 
PDQ Closed Trial Search ID 683739
PDQ Open Trial Search ID 683739 (check for NCI PDQ open clinical trial info)
UMLS CUI C2985185

Other Properties:
     Name Value (qualifiers indented underneath)
code C92576
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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