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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor Debio 0932 (Code C92572)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor Debio 0932

Definition: An orally active and small molecule inhibitor of heat shock protein 90 (Hsp90) with potential antineoplastic activity. Hsp90 inhibitor Debio 0932 specifically blocks Hsp90, thereby inhibiting its chaperone function and promoting the degradation of its client proteins, many of which are oncogenic signaling proteins involved in tumor cell proliferation and survival. This may lead to an inhibition of tumor cell proliferation. Hsp90, a chaperone protein upregulated in a variety of tumor cells, regulates the folding, stabilization and degradation of many oncogenic signaling proteins.

Label: Hsp90 Inhibitor Debio 0932

NCI Thesaurus Code: C92572 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2742735  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Debio 0932
Hsp90 Inhibitor Debio 0932

External Source Codes: 
PDQ Closed Trial Search ID 682685
PDQ Open Trial Search ID 682685 (check for NCI PDQ open clinical trial info)
UMLS CUI C2742735

Other Properties:
     Name Value (qualifiers indented underneath)
code C92572
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92572

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