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Version: 16.11d (Release date: 2016-11-28)
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Ciclopirox Olamine Lotion (Code C92171)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ciclopirox Olamine Lotion

Definition: A lotion preparation of the olamine salt of ciclopirox, a synthetic hydroxypyridone derivative with broad-spectrum antifungal and anti-inflammatory activities. Although its mechanism of action is not well understood, ciclopirox may chelate trivalent cations, such as Fe3+ and Al3+, thereby inhibiting the availability of essential metal co-factors for enzymes, which may result in a loss of enzyme activities that are essential for cellular metabolism, organization of cell wall structure, and other crucial cell functions in a wide variety of fungal species. This agent may also disrupt DNA repair, cell division signals and mitotic spindles as well as some elements of intracellular transport in susceptible fungi. Ciclopirox exhibits anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

Label: Ciclopirox Olamine Lotion

NCI Thesaurus Code: C92171 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421690  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ciclopirox Olamine Lotion
Loprox Lotion

External Source Codes: 
PDQ Closed Trial Search ID 514473
PDQ Open Trial Search ID 514473 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421690

Other Properties:
Name Value (qualifiers indented underneath)
code C92171
Legacy_Concept_Name Ciclopirox
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C92171

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