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Version: 17.06d (Release date: 2017-06-26)
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Eritoran Tetrasodium (Code C91759)

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Terms & Properties

Preferred Name: Eritoran Tetrasodium

Definition: The tetrasodium salt of a synthetic analogue of the lipid A portion of the endotoxin lipopolysaccharide (LPS) with potential immunomodulating activity. Eritoran binds to the Toll-like receptor (TLR)/CD14/MD2 receptor complex present on most cells of the immune system, inhibiting the activation of the receptor complex by LPS, which may result in the inhibition of pro-inflammatory cytokine secretion and a potentially fatal systemic inflammatory response syndrome (SIRS). LPS is found in the outer membrane of Gram-negative bacteria and binds to the TLR/CD14/MD2 receptor complex of immune cells, especially macrophages, resulting in the release of pro-inflammatory cytokines.

Label: Eritoran Tetrasodium

NCI Thesaurus Code: C91759 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0759990  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha-D-glucopyranose,3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-1-(dihydrogen phosphate), Tetrasodium Salt
B1287
E-5564
E5564
ERITORAN TETRASODIUM
Eritoran Tetrasodium

External Source Codes: 
CAS Registry Number 185954-98-7 (see NLM ChemIDplus info)
FDA UNII Code FUO195TC7O
ChEBI ID CHEBI:46692 (see ChEBI info)
PDQ Closed Trial Search ID 616656
PDQ Open Trial Search ID 616656 (check for NCI PDQ open clinical trial info)
UMLS CUI C0759990

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C66H122N2O19P2.4Na
code C91759
Contributing_Source FDA
Legacy_Concept_Name Eritoran
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91759

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