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Version: 17.06d (Release date: 2017-06-26)
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Phaleria macrocarpa Extract DLBS-1425 (Code C91739)

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Terms & Properties

Preferred Name: Phaleria macrocarpa Extract DLBS-1425

Definition: An extract of the flesh from the fruit of Phaleria macrocarpa, an Indonesian herbal medicine, with potential antineoplastic activity. Although the active ingredients and exact components are unclear, gallic acid and its derivatives in DLBS-1425 appear to inhibit the phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) signaling pathway by reducing PI3K transcription followed by a reduction in AKT phosphorylation. This extract also appears to induce apoptosis through induction of pro-apoptotic genes such as BAX, BAD and PUMA and inhibition of the apoptosis suppressor Bcl-2.

Label: Phaleria macrocarpa Extract DLBS-1425

NCI Thesaurus Code: C91739 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984527  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Phaleria macrocarpa Extract DLBS-1425

External Source Codes: 
PDQ Closed Trial Search ID 659153
PDQ Open Trial Search ID 659153 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984527

Other Properties:
     Name Value (qualifiers indented underneath)
code C91739
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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