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Version: 17.12d (Release date: 2017-12-26)
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NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes (Code C91738)

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Terms & Properties

Preferred Name: NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes

Definition: Exosomes loaded with non-small cell lung cancer (NSCLC)-specific antigens, with potential immunostimulating and antineoplastic activities. Exosomes derived from autologous maturing dendritic cells (DCs) are pulsed with HLA-DP04-restricted MAGE-3, and HLA-A02-restricted peptides NY-ESO-1, MAGE-1, MAGE-3, and MART-1. Upon vaccination, these exosomes may stimulate natural killer (NK) cell activation and proliferation, restoration of NKG2D expression on NK cells, and antigen-specific T-cell responses. This may eventually lead to inhibition of tumor cell proliferation in NSCLC expressing these specific tumor antigens. These exosomes, nanovesicles secreted from DCs, are embedded with molecules necessary for potent immune responses on the exosomal surface, such as MHC class II molecules, CD40, ICAM-1, IL-15Ralpha, and NKG2D ligands.

Label: NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes

NCI Thesaurus Code: C91738 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984526  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NSCLC Antigen-Loaded Dendritic Cell-derived Exosomes

External Source Codes: 
PDQ Closed Trial Search ID 681902
PDQ Open Trial Search ID 681902 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984526

Other Properties:
     Name Value (qualifiers indented underneath)
code C91738
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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