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Version: 17.06d (Release date: 2017-06-26)
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Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide (Code C91736)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide

Definition: A liposomal formulation containing the antisense oligodeoxynucleotide (ODN) growth factor receptor-bound protein 2 (Grb2), with potential antineoplastic activity. Upon administration, liposome-incorporated Grb2 antisense oligodeoxynucleotide binds directly to and blocks Grb2 mRNA, thereby preventing Grb2 protein synthesis, leading to inhibition of cell proliferation of cancer cells overexpressing Grb2. Grb2, an adaptor protein involved in growth signaling pathways, is upregulated in certain tumor cells.

Display Name: Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide

Label: Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide

NCI Thesaurus Code: C91736 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421657  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Liposomal Grb2 AS ODN
Liposome-Incorporated Grb2 Antisense Oligodeoxynucleotide

External Source Codes: 
PDQ Closed Trial Search ID 681815
PDQ Open Trial Search ID 681815 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C91736
Contributing_Source CTRP
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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