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Version: 17.06d (Release date: 2017-06-26)
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Vocimagene Amiretrorepvec (Code C91734)

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Terms & Properties

Preferred Name: Vocimagene Amiretrorepvec

Definition: A replication competent retroviral vector, derived from the Moloney murine leukemia virus (MoMLV), encoding a modified form of the yeast suicide gene cytosine deaminase (CD) (Toca 511) used as an antineoplastic adjuvant. Upon transcranial injection, vocimagene amiretrorepvec preferentially enters and transfects tumor cells, and expresses cytosine deaminase, an enzyme that catalyzes the intracellular conversion of the prodrug flucytosine (5-FC) into the antineoplastic agent 5-fluorouracil (5-FU). After administration of 5-FC, the tumor can be eradicated upon activation of 5-FU.

Display Name: Vocimagene Amiretrorepvec

Label: Vocimagene Amiretrorepvec

NCI Thesaurus Code: C91734 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421655  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DNA (Synthetic Toca 511-encoding Retroviral Vector AC3-yCD2(V))
Toca 511
Vocimagene Amiretrorepvec
VOCIMAGENE AMIRETROREPVEC

External Source Codes: 
CAS Registry Number 1300724-82-6 (see NLM ChemIDplus info)
FDA UNII Code DC4WO3WA4Q
PDQ Closed Trial Search ID 681586
PDQ Open Trial Search ID 681586 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421655

Other Properties:
     Name Value (qualifiers indented underneath)
code C91734
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91734

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