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Version: 17.06d (Release date: 2017-06-26)
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Tabalumab (Code C91727)

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Terms & Properties

Preferred Name: Tabalumab

Definition: A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival.

Display Name: Tabalumab

Label: Tabalumab

NCI Thesaurus Code: C91727 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984518  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-BAFF Monoclonal Antibody LY2127399
LY2127399
Tabalumab
TABALUMAB

External Source Codes: 
CAS Registry Number 1143503-67-6 (see NLM ChemIDplus info)
FDA UNII Code PQP8VH3MJW
PDQ Closed Trial Search ID 600180
PDQ Open Trial Search ID 600180 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984518

Other Properties:
     Name Value (qualifiers indented underneath)
code C91727
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91727

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