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Version: 17.06d (Release date: 2017-06-26)
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Tabalumab (Code C91727)

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Terms & Properties

Preferred Name: Tabalumab

Definition: A human IgG4 monoclonal antibody against B-cell activating factor (BAFF), with potential immunomodulating and antineoplastic activities. Tabalumab binds to and inhibits the activity of both soluble and cell surface-bound BAFF. This may reduce the activity, proliferation and survival of B-cells. A dysregulated expression of BAFF, a member of the tumor necrosis factor (TNF) family of proteins, is often seen in certain autoimmune diseases and certain cancers, and may promote B lymphocyte activation, proliferation and survival.

Display Name: Tabalumab

Label: Tabalumab

NCI Thesaurus Code: C91727 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984518  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-BAFF Monoclonal Antibody LY2127399

External Source Codes: 
CAS Registry Number 1143503-67-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 600180
PDQ Open Trial Search ID 600180 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984518

Other Properties:
     Name Value (qualifiers indented underneath)
code C91727
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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