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Version: 16.11d (Release date: 2016-11-28)
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WEE1 Inhibitor AZD1775 (Code C91725)

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Terms & Properties

Preferred Name: WEE1 Inhibitor AZD1775

Definition: A small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. AZD1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDK1, CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents. Unlike normal cells, most p53 deficient or mutated human cancers lack the G1 checkpoint as p53 is the key regulator of the G1 checkpoint and these cells rely on the G2 checkpoint for DNA repair to damaged cells. Annulment of the G2 checkpoint may therefore make p53 deficient tumor cells more vulnerable to antineoplastic agents and enhance their cytotoxic effect.

Display Name: WEE1 Inhibitor AZD1775

Label: WEE1 Inhibitor AZD1775

NCI Thesaurus Code: C91725 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2934122  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one
AZD-1775
AZD1775
MK-1775
MK1775
WEE1 Inhibitor AZD1775

External Source Codes: 
CAS Registry Number 955365-80-7 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 594147
PDQ Open Trial Search ID 594147 (check for NCI PDQ open clinical trial info)
UMLS CUI C2934122

Other Properties:
Name Value (qualifiers indented underneath)
code C91725
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91725

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