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Version: 17.06d (Release date: 2017-06-26)
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MDM2 Antagonist RO5045337 (Code C91724)

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Terms & Properties

Preferred Name: MDM2 Antagonist RO5045337

Definition: An MDM2 (human homolog of double minutes-2; HDM2) antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53 signaling and thus the p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger protein, is a negative regulator of the p53 pathway; often overexpressed in cancer cells, it has been implicated in cancer cell proliferation and survival.

Display Name: MDM2 Antagonist RO5045337

Label: MDM2 Antagonist RO5045337

NCI Thesaurus Code: C91724 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421615  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MDM2 Antagonist RO5045337
R7112
RO5045337

External Source Codes: 
PDQ Closed Trial Search ID 581121
PDQ Open Trial Search ID 581121 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421615

Other Properties:
     Name Value (qualifiers indented underneath)
code C91724
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91724

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