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Version: 17.06d (Release date: 2017-06-26)
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Anti-Nucleolin Aptamer AS1411 (Code C91721)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Anti-Nucleolin Aptamer AS1411

Definition: A 26-base guanine-rich oligodeoxynucleotide aptamer with potential apoptotic induction activity. Upon administration, anti-nucleolin aptamer AS1411 targets and binds to nucleolin, a nucleolar phosphoprotein which is overexpressed on the surface of certain cancer cells. Via binding to cell surface nucleolin, AS1411 is internalized and may prevent nucleolin from binding to and stabilizing mRNA of the anti-apoptotic BCL2, thereby destabilizing BCL2 mRNA, leading to a reduction in BCL2 protein synthesis. This may lead to the induction of apoptosis.

Display Name: Anti-Nucleolin Aptamer AS1411

Label: Anti-Nucleolin Aptamer AS1411

NCI Thesaurus Code: C91721 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1744513  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Nucleolin Aptamer AS1411
AS1411

External Source Codes: 
PDQ Closed Trial Search ID 565948
PDQ Open Trial Search ID 565948 (check for NCI PDQ open clinical trial info)
UMLS CUI C1744513

Other Properties:
     Name Value (qualifiers indented underneath)
code C91721
Contributing_Source CTRP
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91721

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