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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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GP2 Peptide/GM-CSF Vaccine (Code C91720)

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Terms & Properties

Preferred Name: GP2 Peptide/GM-CSF Vaccine

Definition: A vaccine containing a HER2/Neu-derived epitope (amino acids 654-662) (GP2), and combined with granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential antineoplastic and immunoadjuvant activity. Upon vaccination, GP2 may activate the immune system to mount a cytotoxic T-lymphocyte (CTL) immune response against HER2/Neu expressing cancer cells. GM-CSF may potentiate a tumor-specific cytotoxic T-lymphocyte (CTL) response against cancer cells expressing the HER2/Neu antigen. HER2/neu, a tumor associated antigen (TAA), is overexpressed in a variety of tumor cell types and is highly immunogenic.

Display Name: GP2 Peptide/GM-CSF Vaccine

Label: GP2 Peptide/GM-CSF Vaccine

NCI Thesaurus Code: C91720 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376183  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GP2 Peptide/GM-CSF Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 564694
PDQ Open Trial Search ID 564694 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C91720
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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