skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
AE37 Peptide/GM-CSF Vaccine (Code C91719)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: AE37 Peptide/GM-CSF Vaccine

Definition: A vaccine containing HER2/Neu-derived epitope (amino acids 776-790) linked to li-Key peptide (li-Key/HER2/neu hybrid peptide or AE37), and combined with granulocyte-macrophage colony-stimulating factor (GM-CSF), with potential antineoplastic and immunoadjuvant activities. Upon vaccination, AE37 may activate the immune system and stimulate T-helper cells against HER2/Neu expressing cancer cells. GM-CSF may potentiate the immune response against cancer cells expressing the HER2/Neu antigen. The Ii-Key moiety, a 4-amino acid (LRMK) epitope from the MHC class II-associated invariant chain (Ii protein), increases T-helper cell stimulation against HER2/neu antigen when compared to unmodified class II epitopes. HER2/neu, a tumor associated antigen (TAA), is overexpressed in a variety of tumor cell types and is highly immunogenic.

Display Name: AE37 Peptide/GM-CSF Vaccine

Label: AE37 Peptide/GM-CSF Vaccine

NCI Thesaurus Code: C91719 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376182  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AE37 Peptide/GM-CSF Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 564693
PDQ Open Trial Search ID 564693 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376182

Other Properties:
Name Value (qualifiers indented underneath)
code C91719
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91719

Mainbox Bottom