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Version: 16.10e (Release date: 2016-10-31)
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Trebananib (Code C91711)

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Terms & Properties

Preferred Name: Trebananib

Definition: An angiopoietin (Ang) 1 and 2 neutralizing peptibody, with potential antiangiogenic activity. AMG 386 targets and binds to Ang1 and Ang2, thereby preventing the interaction of the angiopoietins with their target tie2 receptors. This may inhibit angiogenesis and may eventually lead to an inhibition of tumor cell proliferation.

Display Name: Trebananib

Label: Trebananib

NCI Thesaurus Code: C91711 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3660912  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 386
Angiopoietin 1/2-Neutralizing Peptibody AMG 386
Trebananib
TREBANANIB

External Source Codes: 
CAS Registry Number 894356-79-7 (see NLM ChemIDplus info)
FDA UNII Code X8Y5U6NC7E
PDQ Closed Trial Search ID 423474
PDQ Open Trial Search ID 423474 (check for NCI PDQ open clinical trial info)
UMLS CUI C3660912

Other Properties:
Name Value (qualifiers indented underneath)
code C91711
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91711

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