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Version: 17.06d (Release date: 2017-06-26)
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Urokinase-Derived Peptide A6 (Code C91709)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Urokinase-Derived Peptide A6

Definition: An octapeptide (amino acids 136-143) derived from the proteolytic enzyme urokinase plasminogen activator (uPA), with potential antineoplastic activity. A6 is derived from the nonreceptor-binding domain and connecting region of urokinase. Administration of A6 inhibits the interaction of uPA with its receptor uPAR, and may inhibit endothelial cell motility and tumor cell invasion. uPA and uPAR promote extracellular matrix degradation and growth factor activation and correlate positively with angiogenesis, cancer cell invasion and metastasis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. A6 is a small piece of a protein called urokinase (an enzyme that dissolves blood clots or prevents them from forming). It is a type of antiangiogenesis agent and a type of antimetastatic agent.

Display Name: Urokinase-Derived Peptide A6

Label: Urokinase-Derived Peptide A6

NCI Thesaurus Code: C91709 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL433998  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
A6
uPA-derived Peptide A6
Urokinase-Derived Peptide A6
urokinase plasminogen activator (uPA)-derived peptide A6

External Source Codes: 
PDQ Closed Trial Search ID 377541
PDQ Open Trial Search ID 377541 (check for NCI PDQ open clinical trial info)
NCI META CUI CL433998

Other Properties:
     Name Value (qualifiers indented underneath)
code C91709
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91709

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