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Version: 16.11d (Release date: 2016-11-28)
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DOTAP:Cholesterol-Fus1 Liposome Complex (Code C91708)

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Terms & Properties

Preferred Name: DOTAP:Cholesterol-Fus1 Liposome Complex

Definition: A formulation composed of DOTAP:cholesterol liposomal nanoparticles complexed with a plasmid expression cassette encoding human FUS1 protein, with potential antineoplastic activity. Upon administration, DOTAP:chol-Fus1 liposome complex accumulates mainly in the lungs and particularly in cancer cells. Upon transfer of the Fus1 gene into tumor cells, the expression of Fus1 may induce tumor cell apoptosis and suppress tumor cell proliferation. Fus1, a potent tumor-suppressor protein, is present in normal, healthy cells but often absent in certain cancer cells. DOTAP:cholesterol liposome is composed of cationic lipid dioleoyl-trimethylammonium propane (DOTAP) and cholesterol at a molar ratio of 1:1.

Display Name: DOTAP:Cholesterol-Fus1 Liposome Complex

Label: DOTAP:Cholesterol-Fus1 Liposome Complex

NCI Thesaurus Code: C91708 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1541286  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DOTAP:Cholesterol-Fus1 Liposome Complex
INGN 401

External Source Codes: 
PDQ Closed Trial Search ID 372908
PDQ Open Trial Search ID 372908 (check for NCI PDQ open clinical trial info)
UMLS CUI C1541286

Other Properties:
Name Value (qualifiers indented underneath)
code C91708
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91708

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