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Version: 17.12d (Release date: 2017-12-26)
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Galactomannan Derivative (Code C91703)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Galactomannan Derivative

Definition: A carbohydrate polymer composed of mannose and galactose, with chemotherapeutic enhancing activity. Galactomannan derivative binds to galectins on cell surfaces and may promote the transport of certain chemotherapeutics, such as 5-fluorouracil (5-FU), into tumor cells. This may increase the antineoplastic effect of 5-FU when administered concomitantly. Galectins are carbohydrate-binding proteins, upregulated on the surface of certain types of tumor cells, and may mediate cell association, survival and metastasis.

Display Name: Galactomannan Derivative

Label: Galactomannan Derivative

NCI Thesaurus Code: C91703 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328725  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Galactomannan Derivative

External Source Codes: 
PDQ Closed Trial Search ID 355829
PDQ Open Trial Search ID 355829 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328725

Other Properties:
     Name Value (qualifiers indented underneath)
code C91703
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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