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Version: 17.06d (Release date: 2017-06-26)
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Pegylated Arginine Deiminase (Code C91702)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pegylated Arginine Deiminase

Definition: An agent consisting of the arginine-degrading enzyme arginine deiminase combined with polyethylene glycol (20,000 MW) (ADI-PEG 20) with potential antineoplastic activity. Upon administration, arginine deiminase breaks down the amino acid arginine into citrulline. Although arginine is a nonessential amino acid for normal human cells, certain cancer cells are autotrophic for arginine and need arginine in order to survive. Depletion of arginine may lead to an inhibition of cellular proliferation in those cancer cells. ADI is coupled to PEG in order to enhance this agent's half-life.

NCI-GLOSS Definition: A substance being studied in the treatment of melanoma, liver cancer, and other types of cancer. It breaks down the amino acid arginine and may block the growth of cancer cells that need arginine to grow. It is a type of iminohydrolase.

Display Name: Pegylated Arginine Deiminase

Label: Pegylated Arginine Deiminase

NCI Thesaurus Code: C91702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1328192  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADI-PEG 20
Pegylated Arginine Deiminase
pegylated arginine deiminase

External Source Codes: 
PDQ Closed Trial Search ID 355725
PDQ Open Trial Search ID 355725 (check for NCI PDQ open clinical trial info)
UMLS CUI C1328192

Other Properties:
     Name Value (qualifiers indented underneath)
code C91702
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91702

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