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Version: 16.11d (Release date: 2016-11-28)
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JAK2 Inhibitor AZD1480 (Code C91394)

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Terms & Properties

Preferred Name: JAK2 Inhibitor AZD1480

Definition: An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.

Display Name: JAK2 Inhibitor AZD1480

Label: JAK2 Inhibitor AZD1480

NCI Thesaurus Code: C91394 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2745423  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD1480
JAK2 Inhibitor AZD1480

External Source Codes: 
PDQ Closed Trial Search ID 672901
PDQ Open Trial Search ID 672901 (check for NCI PDQ open clinical trial info)
UMLS CUI C2745423

Other Properties:
Name Value (qualifiers indented underneath)
code C91394
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91394

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