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Version: 17.06d (Release date: 2017-06-26)
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p70S6K Inhibitor LY2584702 (Code C91393)

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Terms & Properties

Preferred Name: p70S6K Inhibitor LY2584702

Definition: An orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. p70S6K inhibitor LY2584702 inhibits ribosomal protein S6 Kinase (p70S6K), and prevents phosphorylation of the S6 subunit of ribosomes, thereby inhibiting normal ribosomal function within tumor cells leading to a decrease in protein synthesis and in cellular proliferation. P70S6K, a serine/threonine kinase, acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway, is often upregulated in a variety of cancer cells, and is involved in the regulation of cell growth, proliferation, motility, and survival.

Label: p70S6K Inhibitor LY2584702

NCI Thesaurus Code: C91393 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984214  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LY2584702
p70S6K Inhibitor LY2584702

External Source Codes: 
PDQ Closed Trial Search ID 673507
PDQ Open Trial Search ID 673507 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984214

Other Properties:
     Name Value (qualifiers indented underneath)
code C91393
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91393

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