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Version: 17.08d (Release date: 2017-08-28)
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Prexasertib (Code C91392)

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Terms & Properties

Preferred Name: Prexasertib

Definition: An inhibitor of checkpoint kinase 1 (chk1) with potential antineoplastic activity. Upon administration, prexasertib selectively binds to chk1, thereby preventing activity of chk1 and abrogating the repair of damaged DNA. This may lead to an accumulation of damaged DNA and may promote genomic instability and apoptosis. Prexasertib may potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapeutic agents. Chk1, a serine/threonine kinase, mediates cell cycle checkpoint control and is essential for DNA repair and plays a key role in resistance to chemotherapeutic agents.

Display Name: Prexasertib

Label: Prexasertib

NCI Thesaurus Code: C91392 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984213  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Pyrazinecarbonitrile, 5-((5-(2-(3-Aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)-

External Source Codes: 
CAS Registry Number 1234015-52-1 (see NLM ChemIDplus info)
FDA UNII Code 820NH671E6
PDQ Closed Trial Search ID 673506
PDQ Open Trial Search ID 673506 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984213

Other Properties:
     Name Value (qualifiers indented underneath)
code C91392
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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