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Version: 17.06d (Release date: 2017-06-26)
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Deuterated 3-Methylhistidine (Code C91391)

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Terms & Properties

Preferred Name: Deuterated 3-Methylhistidine

Definition: A derivative of the amino acid histidine labeled with heavy hydrogen (D) used in diagnostic procedures. Upon intake of deuterated 3-methylhistidine (3-MH), this agent is incorporated into muscle protein and then is subsequently excreted unchanged in the urine. By measuring the amount of 3-MH in the urine, via analysis of deuterium, the rate of protein muscle catabolism can be determined and the risk of skeletal muscle atrophy or cachexia can be assessed. 3-methylhistidine is a myofibrillar-specific amino acid and is mainly found in muscle myosin and actin; proteolysis of myofibrils releases 3-MH that is excreted unchanged in the urine.

Label: Deuterated 3-Methylhistidine

NCI Thesaurus Code: C91391 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421639  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Deuterated 3-Methylhistidine

External Source Codes: 
PDQ Closed Trial Search ID 681049
PDQ Open Trial Search ID 681049 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421639

Other Properties:
     Name Value (qualifiers indented underneath)
code C91391
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91391

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