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Version: 17.12d (Release date: 2017-12-26)
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Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP (Code C91389)

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Terms & Properties

Preferred Name: Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP

Definition: An iodine 131 radioimmunoconjugate of a small immunoprotein (SIP), derived from the variable region fragment of human monoclonal antibody L19, that is directed against the extra-domain B (ED-B) of fibronectin, with potential radioimmunotherapeutic activity. The SIP moiety of iodine I 131 anti-fibronectin antibody fragment L19-SIP binds to the ED-B domain of fibronectin on tumor cells in the tumor neovasculature. Upon internalization, the I 131 radionuclide may selectively detect or deliver cytotoxic radiation to fibronectin-expressing tumor cells. ED-B of fibronectin, a naturally occurring marker of tissue remodeling and angiogenesis, is expressed in the majority of aggressive solid human tumors, whereas it is not detectable in normal vessels and tissues.

Label: Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP

NCI Thesaurus Code: C91389 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421588  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Iodine I 131 Anti-Fibronectin Antibody Fragment L19-SIP

External Source Codes: 
PDQ Closed Trial Search ID 674133
PDQ Open Trial Search ID 674133 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C91389
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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