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Version: 17.06d (Release date: 2017-06-26)
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PARP Inhibitor E7016 (Code C91387)

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Terms & Properties

Preferred Name: PARP Inhibitor E7016

Definition: An inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemo- and/or radiosensitizing activity. PARP inhibitor E7016 selectively binds to PARP and prevents PARP mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks and promotes genomic instability and eventually leads to apoptosis. In addition, this agent may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell resistance to chemotherapy and radiation therapy. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and is activated by single-strand DNA breaks.

Display Name: PARP Inhibitor E7016

Label: PARP Inhibitor E7016

NCI Thesaurus Code: C91387 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421589  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
E7016
PARP Inhibitor E7016

External Source Codes: 
PDQ Closed Trial Search ID 674406
PDQ Open Trial Search ID 674406 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421589

Other Properties:
     Name Value (qualifiers indented underneath)
code C91387
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91387

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