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Version: 17.06d (Release date: 2017-06-26)
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Flanvotumab (Code C91384)

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Terms & Properties

Preferred Name: Flanvotumab

Definition: A monoclonal antibody directed against the melanosomal membrane protein gp75 (or Tyrosinase-Related Protein 1 (TRP1)) with potential immunostimulatory and antineoplastic activities. Anti-gp75 monoclonal antibody IMC-20D7S targets and binds to gp75. This may lead to the induction of cytotoxic T cell immune and antibody-mediated immune responses against melanoma cells expressing gp75. gp75, a pigmentation-associated antigen, is expressed in melanosomes of human melanocytes and melanomas.

Display Name: Flanvotumab

Label: Flanvotumab

NCI Thesaurus Code: C91384 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421598  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-gp75 Monoclonal Antibody IMC-20D7S
Flanvotumab
FLANVOTUMAB
IMC-20D7S
IMC20D7S

External Source Codes: 
CAS Registry Number 1188277-05-5 (see NLM ChemIDplus info)
FDA UNII Code ZNV4738BS6
PDQ Closed Trial Search ID 675217
PDQ Open Trial Search ID 675217 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421598

Other Properties:
     Name Value (qualifiers indented underneath)
code C91384
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91384

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