skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.10e (Release date: 2016-10-31)
SearchBox Top
SearchBox Bottom
Narnatumab (Code C91382)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Narnatumab

Definition: A fully human monoclonal antibody against RON (recepteur d'origine nantais; macrophage stimulating 1 receptor), with potential antineoplastic activity. Anti-RON monoclonal antibody IMC-RON8 binds to RON, thereby preventing binding of its ligand hepatocyte growth factor-like protein (HGFL or macrophage-stimulating protein (MSP)). This may prevent RON receptor-mediated signaling and may prevent cellular proliferation in tumor cells overexpressing RON. RON, a receptor tyrosine kinase, is overexpressed in a variety of epithelial cancer cell types and plays an important role in cellular proliferation, migration and invasion.

Display Name: Narnatumab

Label: Narnatumab

NCI Thesaurus Code: C91382 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421584  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-RON Monoclonal Antibody IMC-RON8
IMC-RON8
Narnatumab
NARNATUMAB

External Source Codes: 
CAS Registry Number 1188275-92-4 (see NLM ChemIDplus info)
FDA UNII Code R42YK40U9M
PDQ Closed Trial Search ID 673714
PDQ Open Trial Search ID 673714 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421584

Other Properties:
Name Value (qualifiers indented underneath)
code C91382
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91382

Mainbox Bottom