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Version: 17.06d (Release date: 2017-06-26)
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Melanoma TRP2 CTL Epitope Vaccine SCIB1 (Code C91380)

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Terms & Properties

Preferred Name: Melanoma TRP2 CTL Epitope Vaccine SCIB1

Definition: A proprietary DNA-based cancer vaccine that encodes a melanoma antigen tyrosinase-related protein 2 (TRP2) cytotoxic T-lymphocyte (CTL) epitope and a modified monoclonal antibody, a chimera of human IgG1/murine IgG2a with T cell mimotopes expressed within the complementarity-determining regions (CDR) of the antibodies, with potential immunostimulating and antineoplastic activities. Upon intramuscular injection and electroporation, melanoma TRP2 CTL epitope vaccine SCIB1 expresses the modified antibody. Subsequently, the Fc component of the engineered antibody targets and binds to the CD64 receptor on the dendritic cells (DCs); upon processing by DCs, the cellular immune system may be activated to induce helper T-cell and CTL immune responses against tumor cells expressing the TRP2 antigen.

Label: Melanoma TRP2 CTL Epitope Vaccine SCIB1

NCI Thesaurus Code: C91380 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421601  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Melanoma TRP2 CTL Epitope Vaccine SCIB1
SCIB1

External Source Codes: 
PDQ Closed Trial Search ID 675320
PDQ Open Trial Search ID 675320 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421601

Other Properties:
     Name Value (qualifiers indented underneath)
code C91380
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91380

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