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Version: 17.10e (Release date: 2017-10-30)
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GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine (Code C91377)

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Terms & Properties

Preferred Name: GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine

Definition: A trivalent cancer vaccine containing the ganglioside lactones GM2, GD2 and GD3 conjugated with the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Vaccination with GM2 lactone/GD2 lactone/GD3 lactone-KLH conjugate trivalent vaccine may elicit antibodies against tumor cells expressing any of these epitopes, resulting in an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing these gangliosides. GM2, GD2 and GD3 are tumor associated antigens (TAAs) that are overexpressed in a variety of tumor cell membranes.

Display Name: GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine

Label: GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine

NCI Thesaurus Code: C91377 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421633  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GM2/GD2/GD3 Lactone-KLH Conjugate Trivalent Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 680847
PDQ Open Trial Search ID 680847 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C91377
Contributing_Source CTRP
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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