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Version: 16.11d (Release date: 2016-11-28)
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Ciclopirox Olamine Oral (Code C91375)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ciclopirox Olamine Oral

Definition: An aqueous suspension of the olamine salt form of ciclopirox, a synthetic, broad-spectrum hydroxypyridone antifungal agent with additional antibacterial and anti-inflammatory activities. Although the exact mechanism of action of ciclopirox has yet to be fully elucidated, this agent is able to chelate trivalent cations, such as Fe3+, thereby inhibiting the availability of essential co-factors for enzymes. This may lead to a loss of activity of enzymes that are essential for cellular metabolism, organization of cell wall structure and other crucial cell functions. In addition, ciclopirox exerts its anti-inflammatory activity by inhibiting 5-lipoxygenase and cyclooxygenase (COX).

Label: Ciclopirox Olamine Oral

NCI Thesaurus Code: C91375 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421572  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ciclopirox Olamine Oral

External Source Codes: 
PDQ Closed Trial Search ID 672648
PDQ Open Trial Search ID 672648 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421572

Other Properties:
Name Value (qualifiers indented underneath)
code C91375
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91375

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