skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Adenoviral Vector Ad5-CEA(6D) Vaccine (Code C91373)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Adenoviral Vector Ad5-CEA(6D) Vaccine

Definition: A replication-defective, E1- and E2b-deleted oncolytic adenoviral serotype 5 (Ad5) encoding an epitope of human carcinoembryonic antigen (CEA) with potential antineoplastic activity. Adenoviral vector Ad5-CEA(6D) vaccine expresses a highly immunogenic analogue of CEA [CAP1-(6D)]. Upon administration, this vaccine may induce both humoral and cellular immune responses against tumor cells expressing the CEA antigen, thereby resulting in the immune-mediated inhibition of tumor cell proliferation and tumor cell death. CEA, a tumor-associated antigen, is overexpressed in various tumor cell types. Deletion of early genes E1 and E2b in Ad5 potentially circumvent pre-existing anti-adenovirus immunity and is capable of inducing strong immune responses.

Display Name: Adenoviral Vector Ad5-CEA(6D) Vaccine

Label: Adenoviral Vector Ad5-CEA(6D) Vaccine

NCI Thesaurus Code: C91373 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421635  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad5 CEA Vaccine
Adenoviral Vector Ad5-CEA(6D) Vaccine
ETBX-011

External Source Codes: 
PDQ Closed Trial Search ID 680931
PDQ Open Trial Search ID 680931 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421635

Other Properties:
     Name Value (qualifiers indented underneath)
code C91373
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91373

Mainbox Bottom