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Version: 17.10e (Release date: 2017-10-30)
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VEGF Inhibitor PTC299 (Code C91100)

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Terms & Properties

Preferred Name: VEGF Inhibitor PTC299

Definition: An orally bioavailable, small molecule inhibitor of vascular endothelial growth factor (VEGF) synthesis with potential antiangiogenesis and antineoplastic activities. VEGF inhibitor PTC299 targets post-transcriptionally by selectively binding the 5'- and 3'-untranslated regions (UTR) of VEGF messenger RNA (mRNA), thereby preventing translation of VEGF. This inhibits VEGF protein production and decreases its levels in the tumor and bloodstream. In turn, this may result in the inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and eventually the induction of tumor cell death. VEGFs are upregulated in a variety of tumor cell types and play key roles during angiogenesis. In addition, PTC299 may enhance the antitumor activity of other chemotherapeutic agents.

Display Name: VEGF Inhibitor PTC299

Label: VEGF Inhibitor PTC299

NCI Thesaurus Code: C91100 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984037  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PTC299
VEGF Inhibitor PTC299

External Source Codes: 
PDQ Closed Trial Search ID 564407
PDQ Open Trial Search ID 564407 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984037

Other Properties:
     Name Value (qualifiers indented underneath)
code C91100
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&ns=ncit&code=C91100

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