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Version: 17.06d (Release date: 2017-06-26)
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Sodium Metaarsenite (Code C91098)

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Terms & Properties

Preferred Name: Sodium Metaarsenite

Definition: A highly soluble, orally available trivalent arsenic-containing telomerase inhibitor with potential antitumor activity. Although the exact mechanism through which sodium metaarsenite exerts its effect has yet to be fully elucidated, this agent appears to target and bind to telomeric sequences, specifically TTAGGG repeats, leading to a shortening of telomeres, and subsequent induction of apoptosis and inhibition of tumor cell growth. In addition, sodium metaarsenite also leads to the translocation of the catalytic subunit of telomerase into the cytoplasm and inhibition of the activity of telomerase. Telomerase is active in most tumors cells and is responsible for the maintenance of telomere length and plays a key role in cellular proliferation, but is quiescent in normal, healthy cells. The susceptibility to sodium metaarsenite seems to be inversely correlated with initial length of telomeres.

Display Name: Sodium Metaarsenite

Label: Sodium Metaarsenite

NCI Thesaurus Code: C91098 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0074719  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Sodium Arsenite
Sodium Metaarsenite

External Source Codes: 
CAS Registry Number 7784-46-5 (see NLM ChemIDplus info)
ChEBI ID CHEBI:29678 (see ChEBI info)
PDQ Closed Trial Search ID 672554
PDQ Open Trial Search ID 672554 (check for NCI PDQ open clinical trial info)
UMLS CUI C0074719

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula AsO2.Na
code C91098
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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