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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Attenuated Salmonella typhimurium Expressing IL-2 (Code C91096)

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Terms & Properties

Preferred Name: Recombinant Attenuated Salmonella typhimurium Expressing IL-2

Definition: An orally available, genetically engineered Salmonella typhimurium strain expressing a truncated form of the human cytokine interleukin-2 (IL-2) gene, with antitumor activity. Upon administration of recombinant attenuated S. typhimurium expressing IL-2 (SalpIL2), this Salmonella strain may selectively accumulate and divide in a variety of tumor types, and express IL-2. In turn, IL-2 may induce natural killer (NK) cell proliferation thereby enhancing their activity. This may inhibit the growth of tumor cells.

Display Name: Recombinant Attenuated Salmonella typhimurium Expressing IL-2

Label: Recombinant Attenuated Salmonella typhimurium Expressing IL-2

NCI Thesaurus Code: C91096 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421482  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Attenuated Salmonella typhimurium Expressing IL-2

External Source Codes: 
PDQ Closed Trial Search ID 672505
PDQ Open Trial Search ID 672505 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421482

Other Properties:
     Name Value (qualifiers indented underneath)
code C91096
Contributing_Source CTRP
Semantic_Type Bacterium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91096

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