skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Carboxyamidotriazole Orotate (Code C91090)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carboxyamidotriazole Orotate

Definition: The orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis.

Display Name: Carboxyamidotriazole Orotate

Label: Carboxyamidotriazole Orotate

NCI Thesaurus Code: C91090 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421478  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2,3-Carboxyamido-triazole Orotate
Carboxyamidotriazole Orotate
CTO

External Source Codes: 
PDQ Closed Trial Search ID 671851
PDQ Open Trial Search ID 671851 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421478

Other Properties:
     Name Value (qualifiers indented underneath)
code C91090
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91090

Mainbox Bottom