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Version: 16.11d (Release date: 2016-11-28)
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Docetaxel-PNP (Code C91087)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Docetaxel-PNP

Definition: A polymeric nanoparticle (PNP) formulation containing the taxane docetaxel, a semi-synthetic analogue of paclitaxel, with antineoplastic activity. Docetaxel binds specifically to the beta-tubulin subunit of the microtubule, stabilizing tubulin and inhibiting microtubule disassembly, which results in cell-cycle arrest at the G2/M phase, preventing cell proliferation. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and induces various mediators of the inflammatory response. Compared to docetaxel alone, the PNP formulation may enhance stability and improve delivery.

Label: Docetaxel-PNP

NCI Thesaurus Code: C91087 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL421475  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Docetaxel-PNP

External Source Codes: 
PDQ Closed Trial Search ID 671819
PDQ Open Trial Search ID 671819 (check for NCI PDQ open clinical trial info)
NCI META CUI CL421475

Other Properties:
Name Value (qualifiers indented underneath)
code C91087
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91087

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