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Version: 17.12d (Release date: 2017-12-26)
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Uracil Ointment (Code C91083)

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Terms & Properties

Preferred Name: Uracil Ointment

Definition: A 0.1% topical formulation of uracil used potentially to lower the incidence of hand-foot syndrome (HFS) (or palmar-plantar erythrodysesthesia) during 5-fluorouracil (5-FU) or 5-FU prodrug capecitabine chemotherapy. Upon local administration of uracil ointment to the skin, uracil competes with capecitabine or 5-FU as substrates for the activating enzyme thymidine phosphorylase and the metabolizing enzyme dihydropyrimidine dehydrogenase. This may prevent the production of 5-FU as well as the breakdown of 5-FU into the toxic metabolites locally. As the 5-FU metabolites are responsible for the presentation of HFS, inhibiting their formation may prevent this adverse effect. By applying a high concentration of uracil locally, the skin toxicities of 5-FU may be countered while preserving the systemic anti-cancer activity of the 5FU.

Label: Uracil Ointment

NCI Thesaurus Code: C91083 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL416292  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Uracil Ointment

External Source Codes: 
PDQ Closed Trial Search ID 670894
PDQ Open Trial Search ID 670894 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C91083
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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