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Version: 17.06d (Release date: 2017-06-26)
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Smac Mimetic LCL161 (Code C91079)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Smac Mimetic LCL161

Definition: An orally bioavailable second mitochondrial-derived activator of caspases (SMAC) mimetic and inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins, with potential antineoplastic activity. SMAC mimetic LCL161 binds to IAPs, such as X chromosome-linked IAP (XIAP) and cellular IAPs 1 and 2. Since IAPs shield cancer cells from the apoptosis process, this agent may restore and promote the induction of apoptosis through apoptotic signaling pathways in cancer cells. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding and inhibiting active caspases-3, -7 and -9, which play essential roles in apoptosis (programmed cell death), necrosis and inflammation.

Display Name: Smac Mimetic LCL161

Label: Smac Mimetic LCL161

NCI Thesaurus Code: C91079 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984020  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LCL161
Smac Mimetic LCL161

External Source Codes: 
PDQ Closed Trial Search ID 670651
PDQ Open Trial Search ID 670651 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984020

Other Properties:
     Name Value (qualifiers indented underneath)
code C91079
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91079

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