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Version: 16.11d (Release date: 2016-11-28)
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Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907 (Code C91077)

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Terms & Properties

Preferred Name: Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907

Definition: A lipid-based multi-peptide cancer vaccine targeted against multiple cancers with immunopotentiating activity. Therapeutic breast/ovarian/prostate peptide cancer vaccine DPX-0907 is a lyophilized liposomal proprietary preparation comprised of 7 tumor-specific HLA-A2-restricted epitopes (TAAs): Topoisomerase II alpha, B-cell receptor-associated protein 31 (CDM protein), TNF-alpha-converting enzyme (TACE/ADAM17), Abelson homolog 2 (Abl2), gamma catenin (Junction plakoglobin), epithelial discoidin domain receptor 1 (EDDR1) and integrin beta 8 subunit. Upon vaccination, the lyophilized antigen/adjuvant/liposome complex is re-suspended in Montanide 1SA51 VG to create a depot effect, thereby presenting the TAAs to the immune system for a prolonged period of time. This may stimulate a potent cytotoxic T-lymphocyte (CTL) immune response against cancer cells that express these 7 TAAs and share epitopes with the vaccine epitope peptides, resulting in tumor cell lysis. The 7 TAAs are overexpressed on the surface of breast/ovarian and prostate cancer cells and play an important role in tumor cell growth and survival.

Display Name: Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907

Label: Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907

NCI Thesaurus Code: C91077 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984018  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DPX-0907
Therapeutic Breast/Ovarian/Prostate Peptide Cancer Vaccine DPX-0907

External Source Codes: 
PDQ Closed Trial Search ID 670456
PDQ Open Trial Search ID 670456 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984018

Other Properties:
Name Value (qualifiers indented underneath)
code C91077
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91077

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