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Version: 17.06d (Release date: 2017-06-26)
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Ipatasertib (Code C91072)

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Terms & Properties

Preferred Name: Ipatasertib

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Akt Inhibitor GDC-0068

Label: Ipatasertib

NCI Thesaurus Code: C91072 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984014  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(2S)-2-(4-chlorophenyl)-1-(4-((5r,7r)-7-hydroxy-5-methyl-6,7-dihydro-5h-cyclopenta(d)pyrimidin-4-yl)piperazin-1-yl(-3-((propan-2-yl)amino)propan-1-one
Akt Inhibitor GDC-0068
GDC-0068
IPATASERTIB
Ipatasertib
RG-7440

External Source Codes: 
CAS Registry Number 1001264-89-6 (see NLM ChemIDplus info)
FDA UNII Code 524Y3IB4HQ
PDQ Closed Trial Search ID 669600
PDQ Open Trial Search ID 669600 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984014

Other Properties:
     Name Value (qualifiers indented underneath)
code C91072
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91072

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