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Version: 17.06d (Release date: 2017-06-26)
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Ipatasertib (Code C91072)

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Terms & Properties

Preferred Name: Ipatasertib

Definition: An orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Ipatasertib binds to and inhibits the activity of Akt in a non-ATP-competitive manner, which may result in the inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Display Name: Akt Inhibitor GDC-0068

Label: Ipatasertib

NCI Thesaurus Code: C91072 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2984014  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt Inhibitor GDC-0068

External Source Codes: 
CAS Registry Number 1001264-89-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 669600
PDQ Open Trial Search ID 669600 (check for NCI PDQ open clinical trial info)
UMLS CUI C2984014

Other Properties:
     Name Value (qualifiers indented underneath)
code C91072
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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