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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 Choline (Code C91071)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 Choline

Definition: A radioconjugate composed of choline labeled with the positron-emitting isotope fluorine F 18, with potential tumor tracer activity using positron emission tomography (PET). Fluorine F 18 fluorocholine incorporates into tumor cells through an active, carrier-mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, yielding a phosphoryl derivative, that is integrated into the cell membrane as part of phosphatidylcholine. Since the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of fluorine F 18 fluorocholine uptake and incorporation, facilitating imaging of the tumor using PET. Choline kinase, the enzyme responsible for the phosphorylation of choline, is frequently upregulated in human tumor cells. Choline is essential for the production of phosphatidylcholine, which is an important element of phospholipids in cell membranes.

Label: Fluorine F 18 Choline

NCI Thesaurus Code: C91071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1744278  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-Fluorocholine
[18F]-Choline
F-18-FCH
Fluorine F 18 Choline
FLUOROCHOLINE F-18

External Source Codes: 
CAS Registry Number 475572-73-7 (see NLM ChemIDplus info)
FDA UNII Code 700YTQ6F2B
PDQ Closed Trial Search ID 744419
PDQ Open Trial Search ID 744419 (check for NCI PDQ open clinical trial info)
UMLS CUI C1744278

Other Properties:
     Name Value (qualifiers indented underneath)
code C91071
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C91071

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