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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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Hsp90 Inhibitor SNX-5422 Mesylate (Code C91068)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor SNX-5422 Mesylate

Definition: The orally bioavailable mesylate salt of a synthetic prodrug targeting the human heat-shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX-5422 is rapidly converted to SNX-2112, which accumulates more readily in tumors relative to normal tissues. SNX-2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2/ERBB2, and the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as HER2/ERBB2, AKT, RAF1, BCR-ABL, and mutated p53, as well as many other molecules that are important in cell cycle regulation or immune responses.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. SNX-5422 mesylate blocks a protein needed for cells to grow and may kill cancer cells. It is a type of heat shock protein 90 inhibitor.

Display Name: Hsp90 Inhibitor SNX-5422 Mesylate

Label: Hsp90 Inhibitor SNX-5422 Mesylate

NCI Thesaurus Code: C91068 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3253587  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Hsp90 Inhibitor SNX-5422 Mesylate
SNX-5422 Mesylate
SNX-5422 mesylate

External Source Codes: 
PDQ Closed Trial Search ID 590712
PDQ Open Trial Search ID 590712 (check for NCI PDQ open clinical trial info)
UMLS CUI C3253587

Other Properties:
     Name Value (qualifiers indented underneath)
code C91068
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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