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Version: 16.10e (Release date: 2016-10-31)
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Trimethoprim-Sulfamethoxazole (Code C909)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Trimethoprim-Sulfamethoxazole

Definition: A synthetic combination of two antibacterial agents, trimethoprim and sulfamethoxazole. This synergistic combination, also known as Co-Trimoxazole, inhibits two sequential steps in the bacterial metabolism of folic acid. Trimethoprim is a pyrimidine inhibitor of dihydrofolate reductase; sulfamethoxazole is a sulfamide inhibitor of bacterial dihydrofolate synthase.

NCI-GLOSS Definition: An antibiotic drug used to treat infection and prevent pneumocystis carinii pneumonia.

Display Name: Trimethoprim-Sulfamethoxazole

Label: Trimethoprim-Sulfamethoxazole

NCI Thesaurus Code: C909 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0041044  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bactrim
Bactrimel
Bactrim DS
Centran
Centrin
Co-Trimoxazole
co-trimoxazole
Cotrim
Cotrimoxazole
Eslectin
Insozalin
Septra
SMZ-TMP
Sulfamethoprim
Sulfatrim
Sulmeprim
TMP-SMX
Trimedin
Trimethoprim-Sulfamethoxazole
trimethoprim-sulfamethoxazole
Trimezole
Uroplus

External Source Codes: 
CAS Registry Number 8064-90-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:3770 (see ChEBI info)
NSC Code 618652 (see NCI DTP info)
PDQ Closed Trial Search ID 39724
PDQ Open Trial Search ID 39724 (check for NCI PDQ open clinical trial info)
UMLS CUI C0041044

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Pneumocystis carinii pneumonia; Various bacterial infections
code C909
Contributing_Source CTRP
Legacy_Concept_Name Trimethoprim-Sulfamethoxazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C909

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