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Version: 17.06d (Release date: 2017-06-26)
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Dabigatran Etexilate Mesylate (Code C90702)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Dabigatran Etexilate Mesylate

Definition: An orally available mesylate salt form of the etexilate prodrug of dabigatran, a benzimidazole and direct thrombin inhibitor with anticoagulant activity. Upon administration, dabigatran etexilate is hydrolyzed by esterases and is converted into dabigatran. Dabigatran reversibly binds to and inhibits the activity of thrombin, a serine protease that converts fibrinogen into fibrin. This disrupts the coagulation cascade and inhibits the formation of blood clots.

Label: Dabigatran Etexilate Mesylate

NCI Thesaurus Code: C90702 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2343849  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Beta-alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]amino]iminomethyl] phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-,ethyl ester, methanesulfonate
BIBR 1048MS
BIBR 1048 MS
DABIGATRAN ETEXILATE MESYLATE
Dabigatran Etexilate Mesylate
Pradaxa

External Source Codes: 
CAS Registry Number 593282-20-3 (see NLM ChemIDplus info)
CAS Registry Number 872728-81-9 (see NLM ChemIDplus info)
FDA UNII Code SC7NUW5IIT
PDQ Closed Trial Search ID 763237
PDQ Open Trial Search ID 763237 (check for NCI PDQ open clinical trial info)
UMLS CUI C2343849

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C34H41N7O5.CH4O3S
code C90702
Contributing_Source FDA
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90702

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