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Version: 17.06d (Release date: 2017-06-26)
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Liothyronine (Code C907)

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Terms & Properties

Preferred Name: Liothyronine

Definition: A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)

Label: Liothyronine

NCI Thesaurus Code: C907 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL414313  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Triiodothyronine
Liothyronine
LIOTHYRONINE
Therapeutic T3
Triiodothyronine

External Source Codes: 
CAS Registry Number 6893-02-3 (see NLM ChemIDplus info)
FDA UNII Code 06LU7C9H1V
ChEBI ID CHEBI:18258 (see ChEBI info)
NSC Code 80203 (see NCI DTP info)
PDQ Closed Trial Search ID 470233
PDQ Open Trial Search ID 470233 (check for NCI PDQ open clinical trial info)
NCI META CUI CL414313

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C15H12I3NO4
code C907
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Triiodothyronine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C907

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