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Version: 16.12d (Release date: 2016-12-27)
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Idarubicin-Eluting Beads (Code C90593)

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Terms & Properties

Preferred Name: Idarubicin-Eluting Beads

Definition: A sustained-release drug delivery embolization system containing small polymeric beads impregnated with the anthracycline antibiotic idarubicin with potential antineoplastic activity. The beads consist of polyvinyl alcohol (PVA) microspheres modified with sulfonic acid groups and loaded with idarubicin. During transarterial chemoembolization (TACE) in the hepatic artery, idarubicin-eluting beads embolize to the tumor vasculature, occlude tumor blood vessels and induce ischemic necrosis of tumor tissue due to mechanical blockage of the tumor vasculature. Simultaneously, idarubicin-eluting beads release cytotoxic idarubicin locally and in a sustained manner. This may result in idarubicin-mediated inhibition of tumor cell proliferation.

Label: Idarubicin-Eluting Beads

NCI Thesaurus Code: C90593 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL413614  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Idarubicin-Eluting Beads

External Source Codes: 
PDQ Closed Trial Search ID 663437
PDQ Open Trial Search ID 663437 (check for NCI PDQ open clinical trial info)
NCI META CUI CL413614

Other Properties:
Name Value (qualifiers indented underneath)
code C90593
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90593

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