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Version: 17.06d (Release date: 2017-06-26)
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STAT3 Inhibitor OPB-31121 (Code C90588)

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Terms & Properties

Preferred Name: STAT3 Inhibitor OPB-31121

Definition: An orally bioavailable inhibitor of signal transducer and activator of transcription 3 (STAT3), with potential antineoplastic activity. OPB-31121 inhibits the phosphorylation of STAT3, which prevents binding of STAT3 to DNA sequences on a variety of STAT3-responsive promoters and may result in the inhibition of STAT3-mediated transcription and, potentially, the inhibition of tumor cell proliferation. STAT3 is constitutively activated in a variety of cancers, contributing to the loss of cell growth control and neoplastic transformation.

Display Name: STAT3 Inhibitor OPB-31121

Label: STAT3 Inhibitor OPB-31121

NCI Thesaurus Code: C90588 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376190  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
OPB-31121
STAT3 Inhibitor OPB-31121

External Source Codes: 
PDQ Closed Trial Search ID 570187
PDQ Open Trial Search ID 570187 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376190

Other Properties:
     Name Value (qualifiers indented underneath)
code C90588
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C90588

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